Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.50 |
| ▸ | CCR8 | P51685 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.42 |
| ▸ | METAP2 | P50579 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10999711 | 0.78 | CYP11B1 (0.46) | MAPTKDM4EALDH1A1THRBL3MBTL1 | |
| SCHEMBL11448878 | 0.78 | MEN1 (0.48) | MAPTKDM4EALDH1A1THRBL3MBTL1 | |
| SCHEMBL13680683 | 0.77 | CYP2A6 (0.50) | CCR1CCR8CYP2A6TGFBR1METAP2 | |
| SCHEMBL3422361 | 0.77 | CCR1 (0.75) | CCR1CCR8CYP2A6MAPTALDH1A1 | |
| SCHEMBL13680450 | 0.76 | CA12 (0.53) | CCR1CCR8CYP2A6MAPTTHRB | |
| SCHEMBL27973522 | 0.76 | CCR1 (0.50) | CCR1CCR8CYP2A6MAPTTGFBR1 | |
| SCHEMBL10999876 | 0.75 | KDM4E (0.48) | MAPTKDM4EALDH1A1THRBL3MBTL1 | |
| SCHEMBL10999258 | 0.75 | MEN1 (0.44) | MAPTKDM4EALDH1A1THRBL3MBTL1 | |
| SCHEMBL10997580 | 0.74 | ALDH1A1 (0.41) | MAPTKDM4EALDH1A1THRBL3MBTL1 | |
| SCHEMBL13680558 | 0.73 | GRIA1 (0.59) | CCR1CCR8CYP2A6TGFBR1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |