Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | TOP2A | P11388 | 3/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.38 |
| ▸ | NQO2 | P16083 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680696 | 0.80 | GSK3B (0.43) | MAPTKDM4ENPC1PKMTDP1 | |
| SCHEMBL13680504 | 0.79 | PLK1 (0.50) | MAPTKDM4EPKMPOLBGSK3B | |
| SCHEMBL13680701 | 0.79 | TOP2A (0.53) | MAPTKDM4ENPC1TDP1GSK3B | |
| SCHEMBL23197679 | 0.77 | TDP1 (0.56) | MAPTKDM4ENPC1TDP1GSK3B | |
| SCHEMBL13680703 | 0.76 | ALDH1A1 (0.46) | MAPTKDM4ENPC1PKMTDP1 | |
| SCHEMBL13681315 | 0.75 | TOP2A (0.44) | MAPTKDM4ENPC1PKMTDP1 | |
| SCHEMBL9629049 | 0.74 | GAA (0.46) | MAPTNPC1POLBL3MBTL1ALDH1A1 | |
| SCHEMBL13680465 | 0.73 | GSK3B (0.61) | MAPTKDM4ENPC1PKMTDP1 | |
| SCHEMBL13680452 | 0.73 | GSK3B (0.61) | MAPTKDM4ENPC1PKMGSK3B | |
| SCHEMBL5655892 | 0.72 | GSK3B (0.64) | MAPTKDM4ENPC1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |