Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.43 |
| ▸ | NQO2 | P16083 | 6/20 | 0.42 |
| ▸ | TOP2A | P11388 | 3/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680701 | 0.83 | TOP2A (0.53) | GSK3BNQO2TOP2ATOP2BALDH1A1 | |
| SCHEMBL23197679 | 0.81 | TDP1 (0.56) | GSK3BNQO2TOP2ATOP2BALDH1A1 | |
| SCHEMBL13680452 | 0.81 | GSK3B (0.61) | GSK3BNQO2ALDH1A1HPGDKDM4E | |
| SCHEMBL13680703 | 0.80 | ALDH1A1 (0.46) | GSK3BNQO2TOP2ATOP2BALDH1A1 | |
| SCHEMBL13680707 | 0.80 | MAPT (0.40) | GSK3BNQO2TOP2ATOP2BALDH1A1 | |
| SCHEMBL13681315 | 0.79 | TOP2A (0.44) | GSK3BNQO2TOP2ATOP2BALDH1A1 | |
| SCHEMBL13680465 | 0.77 | GSK3B (0.61) | GSK3BNQO2ALDH1A1HPGDTDP1 | |
| SCHEMBL13680503 | 0.76 | GSK3B (0.62) | GSK3BNQO2TOP2ATOP2BALDH1A1 | |
| SCHEMBL4444240 | 0.75 | GSK3B (0.57) | GSK3BALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL2319851 | 0.74 | TDP1 (0.48) | GSK3BNQO2ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |