Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10720270 | 0.77 | CA12 (0.46) | RAB9AALDH1A1MAPTNPC1NFKB1 | |
| SCHEMBL3852918 | 0.76 | CA12 (0.44) | ALDH1A1CYP2D6LMNAHPGDHSD17B10 | |
| SCHEMBL10417158 | 0.76 | TRPA1 (0.46) | CHEK1MAP4K4ABL1NTRK1LCK | |
| SCHEMBL7743329 | 0.71 | ADRB1 (0.46) | MAP4K4PDGFRBPIM1FGFR1PDGFRA | |
| SCHEMBL13680767 | 0.71 | ACHE (0.37) | ACHERAB9AALDH1A1MAPTNPC1 | |
| SCHEMBL28414965 | 0.71 | ACHE (0.55) | CHEK1MAP4K4ABL1NTRK1LCK | |
| Hydrochloric Acid SCHEMBL7743489 | 0.70 | ADRB1 (0.45) | MAP4K4PDGFRBPIM1FGFR1PDGFRA | |
| SCHEMBL1254511 | 0.70 | CA12 (0.46) | ALDH1A1NFKB1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL26307961 | 0.70 | CA12 (0.46) | ALDH1A1NFKB1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12434746 | 0.69 | CHRM1 (0.42) | CHEK1MAP4K4ABL1NTRK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |