Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.37 |
| ▸ | ADH1B | P00325 | 1/20 | 0.36 |
| ▸ | ADH1C | P00326 | 1/20 | 0.36 |
| ▸ | ADH1A | P07327 | 1/20 | 0.36 |
| ▸ | ADH7 | P40394 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11330543 | 0.81 | KCNH2 (0.62) | KCNH2BRD4CALM1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27691633 | 0.77 | KCNH2 (0.59) | KCNH2BRD4CALM1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3854280 | 0.76 | MEN1 (0.50) | KCNH2ALDH1A1RAB9A | |
| SCHEMBL9020936 | 0.74 | TAAR1 (0.36) | BRD4ADH1BADH1CADH1AADH7 | |
| SCHEMBL13680923 | 0.74 | HDAC1 (0.59) | ALDH1A1SMN1; SMN2LMNARAB9AL3MBTL1 | |
| SCHEMBL1463893 | 0.73 | PARP1 (0.36) | KCNH2ALDH1A1MAOBNPSR1 | |
| SCHEMBL6193822 | 0.73 | SMN1; SMN2 (0.45) | KCNH2BRD4ALDH1A1SMN1; SMN2MAOB | |
| SCHEMBL13680814 | 0.73 | KCNH2 (0.35) | KCNH2NPSR1 | |
| SCHEMBL13680785 | 0.73 | MTNR1A (0.47) | CALM1ADH1BADH1CADH1AADH7 | |
| SCHEMBL13680820 | 0.73 | CYP3A4 (0.39) | KCNH2ALDH1A1TDP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |