Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28759152 | 0.80 | HDAC1 (0.59) | HDAC1HDAC6HDAC8NOS1RAB9A | |
| SCHEMBL13680920 | 0.78 | RAB9A (0.56) | RAB9AALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL5656467 | 0.76 | HDAC1 (0.55) | HDAC1HDAC6HDAC8NOS1RAB9A | |
| SCHEMBL5659797 | 0.76 | HDAC1 (0.55) | HDAC1HDAC6HDAC8NOS1RAB9A | |
| SCHEMBL10918996 | 0.76 | HDAC1 (0.58) | HDAC1HDAC6HDAC8NOS1RAB9A | |
| SCHEMBL10916542 | 0.76 | HDAC1 (0.53) | HDAC1HDAC6HDAC8RAB9AL3MBTL1 | |
| SCHEMBL26986062 | 0.75 | HDAC1 (0.62) | HDAC1HDAC6HDAC8RAB9AL3MBTL1 | |
| SCHEMBL13680833 | 0.74 | KCNH2 (0.53) | HDAC1HDAC6RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL1809552 | 0.71 | HDAC1 (0.51) | HDAC1HDAC6HDAC8NOS1SLC6A3 | |
| SCHEMBL8222179 | 0.70 | LOXL2 (0.57) | HDAC1HDAC6HDAC8NOS1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |