Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | HCK | P08631 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.32 |
| ▸ | PRKDC | P78527 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13681028 | 0.84 | DYRK1A (0.43) | HSD17B10MEN1KMT2ACYP3A4DYRK1A | |
| SCHEMBL13680990 | 0.74 | PIK3C3 (0.40) | PIK3C3ALDH1A1L3MBTL1RXFP1 | |
| SCHEMBL13680570 | 0.74 | PIK3C3 (0.39) | PIK3C3CYP11B1CYP11B2PIK3CDABL1 | |
| SCHEMBL13680974 | 0.71 | ALDH1A1 (0.35) | CYP11B1CYP11B2ALDH1A1POLBMAPT | |
| SCHEMBL13681020 | 0.70 | ALDH1A1 (0.40) | ALDH1A1POLBMAPTPKMHTT | |
| SCHEMBL13681006 | 0.70 | CYP2C19 (0.39) | ALDH1A1POLBMAPTPKMHTT | |
| SCHEMBL13680859 | 0.70 | ALDH1A1 (0.60) | CYP11B1CYP11B2ALDH1A1POLBMAPT | |
| SCHEMBL13680886 | 0.69 | CYP2A6 (0.64) | PIK3CAPIK3CGALDH1A1POLBMAPT | |
| SCHEMBL13680889 | 0.68 | ALDH1A1 (0.36) | ALDH1A1POLBMAPTPKMHTT | |
| SCHEMBL13680899 | 0.68 | CYP2C19 (0.40) | ALDH1A1POLBMAPTPKMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |