Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13681059 | 0.83 | DYRK1A (0.45) | LMNASMN1; SMN2L3MBTL1ALDH1A1HPGD | |
| SCHEMBL13680906 | 0.74 | PIK3C3 (0.37) | PIK3C3L3MBTL1RXFP1ALDH1A1 | |
| SCHEMBL13680619 | 0.74 | CYP3A4 (0.44) | PIK3C3ACKR3KDM4EALDH1A1HPGD | |
| SCHEMBL13680920 | 0.72 | RAB9A (0.56) | LMNASMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL3603152 | 0.70 | KDM4E (0.59) | LMNASMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL13680926 | 0.70 | LMNA (0.56) | LMNASMN1; SMN2KDM4EALDH1A1RAB9A | |
| SCHEMBL13680943 | 0.70 | RAB9A (0.48) | LMNASMN1; SMN2L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL13680922 | 0.70 | GFER (0.62) | LMNASMN1; SMN2KDM4EALDH1A1RAB9A | |
| SCHEMBL7039927 | 0.69 | KDM4E (0.60) | LMNASMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL13680996 | 0.69 | QPCT (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |