Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680921 | 0.84 | DRD2 (0.48) | LMNAHDAC1HDAC8HDAC6PDE4B | |
| SCHEMBL5544111 | 0.80 | NPC1 (0.48) | LMNANPC1MAPTMAPK1RAB9A | |
| SCHEMBL2225521 | 0.80 | NPC1 (0.51) | LMNANPC1MAPTMAPK1RAB9A | |
| SCHEMBL13680924 | 0.78 | SCN10A (0.44) | LMNANPSR1HDAC1HDAC8HDAC6 | |
| SCHEMBL202513 | 0.77 | NPC1 (0.51) | LMNANPC1MAPTMAPK1RAB9A | |
| SCHEMBL5537952 | 0.76 | NPC1 (0.45) | LMNANPC1MAPTMAPK1RAB9A | |
| SCHEMBL27610597 | 0.76 | NPC1 (0.45) | LMNANPC1MAPTMAPK1RAB9A | |
| SCHEMBL6426163 | 0.76 | NPC1 (0.50) | LMNANPC1MAPTMAPK1RAB9A | |
| SCHEMBL12996293 | 0.76 | NPC1 (0.50) | LMNANPC1MAPTMAPK1RAB9A | |
| SCHEMBL381503 | 0.76 | NOTUM (0.51) | LMNANPC1MAPTMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |