Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1051604 | 0.80 | NOTUM (0.47) | SCN10ANOTUMS1PR1S1PR3PPARG | |
| SCHEMBL14603452 | 0.80 | SCN10A (0.48) | SCN10ANOTUMS1PR1S1PR3PPARG | |
| SCHEMBL13680927 | 0.78 | LMNA (0.45) | PPARGPPARAHDAC1HDAC8HDAC6 | |
| SCHEMBL13680921 | 0.78 | DRD2 (0.48) | PPARGPPARAFFAR1HDAC1HDAC8 | |
| SCHEMBL16399524 | 0.77 | SCN10A (0.48) | SCN10ANOTUMS1PR1S1PR3HDAC3 | |
| SCHEMBL13680824 | 0.75 | SUCNR1 (0.44) | SCN10ASUCNR1HDAC3HDAC1HDAC2 | |
| SCHEMBL13680931 | 0.74 | SHMT2 (0.56) | SCN10ATP53 | |
| SCHEMBL2056110 | 0.72 | SCN10A (0.54) | SCN10ANOTUMS1PR1S1PR3TP53 | |
| SCHEMBL584633 | 0.71 | GPR84 (0.49) | FFAR1 | |
| SCHEMBL28321744 | 0.70 | SCN10A (0.62) | SCN10ANOTUMS1PR1S1PR3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |