Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF1 | P36956 | 1/20 | 0.51 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680933 | 0.80 | SREBF2 (0.51) | SREBF2LMNARAB9ATP53MAPT | |
| SCHEMBL13680926 | 0.80 | LMNA (0.56) | SREBF2LMNARAB9ATP53MAPT | |
| SCHEMBL13680936 | 0.78 | TP53 (0.46) | LMNATP53MAPTHTTMEN1 | |
| SCHEMBL13680934 | 0.78 | TP53 (0.51) | SREBF2HPGDLMNATP53MAPT | |
| SCHEMBL13680938 | 0.78 | MEN1 (0.49) | LMNATP53MAPTKDM4EHTT | |
| SCHEMBL13681034 | 0.78 | MEN1 (0.46) | LMNARAB9ATP53MAPTKDM4E | |
| SCHEMBL13680940 | 0.77 | TP53 (0.45) | LMNARAB9ATP53MAPTHTT | |
| SCHEMBL13680922 | 0.77 | GFER (0.62) | LMNARAB9ATP53MAPTKDM4E | |
| SCHEMBL13680943 | 0.77 | RAB9A (0.48) | SREBF2HPGDLMNARAB9ATP53 | |
| SCHEMBL13680920 | 0.77 | RAB9A (0.56) | HPGDLMNARAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |