Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT1 | P34896 | 1/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 7/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680623 | 0.78 | NPC1 (0.41) | PLA2G10NPC1RAB9ACLK1SMN1; SMN2 | |
| SCHEMBL13680993 | 0.77 | PRF1 (0.53) | LMNASMN1; SMN2GAA | |
| SCHEMBL13681010 | 0.77 | PDE3B (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL13681043 | 0.76 | HSD17B1 (0.42) | LMNASMN1; SMN2KDM4EL3MBTL1RXFP1 | |
| SCHEMBL13680968 | 0.76 | ALDH1A1 (0.35) | SMN1; SMN2KDM4ERXFP1ALDH1A1HPGD | |
| SCHEMBL13681000 | 0.75 | CRBN (0.40) | NPC1RAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL13681013 | 0.74 | PRF1 (0.43) | LMNASMN1; SMN2L3MBTL1RXFP1ALDH1A1 | |
| SCHEMBL13680991 | 0.74 | PDE3B (0.48) | LMNASMN1; SMN2KDM4EL3MBTL1RXFP1 | |
| SCHEMBL13680995 | 0.72 | CDC25A (0.48) | LMNASMN1; SMN2KDM4EL3MBTL1RXFP1 | |
| SCHEMBL13680922 | 0.72 | GFER (0.62) | NPC1RAB9ALMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |