Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.48 |
| ▸ | CDC25B | P30305 | 1/20 | 0.48 |
| ▸ | CDC25C | P30307 | 1/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.37 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13681003 | 0.83 | HRH3 (0.39) | ENPP2LMNASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL13680991 | 0.81 | PDE3B (0.48) | CDC25ACDC25BCDC25CDUSP3PDE3B | |
| SCHEMBL13680986 | 0.80 | GUSB (0.45) | ENPP2MAPT | |
| SCHEMBL13680997 | 0.80 | RAB9A (0.41) | ENPP2LMNASMN1; SMN2KDM4ERXFP1 | |
| SCHEMBL13680981 | 0.79 | GSK3B (0.46) | DYRK1A | |
| SCHEMBL13680996 | 0.78 | QPCT (0.44) | — | |
| SCHEMBL13681000 | 0.76 | CRBN (0.40) | PDE3BPDE3ALMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL13680625 | 0.76 | CDC25A (0.56) | CDC25ACDC25BCDC25CDUSP3PDE3B | |
| SCHEMBL13681061 | 0.75 | LMNA (0.38) | ENPP2LMNASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL13681013 | 0.75 | PRF1 (0.43) | LMNASMN1; SMN2L3MBTL1RXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |