Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | TP53 | P04637 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 7/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680926 | 0.85 | LMNA (0.56) | MAPTTP53LMNAPOLBRAB9A | |
| SCHEMBL13680943 | 0.85 | RAB9A (0.48) | GFERMAPTTP53LMNAPOLB | |
| SCHEMBL13680920 | 0.84 | RAB9A (0.56) | MAPTLMNAPOLBRAB9ANPC1 | |
| SCHEMBL13680937 | 0.81 | KDM4E (0.52) | MAPTTP53LMNARAB9AMEN1 | |
| SCHEMBL13680929 | 0.81 | ALDH1A1 (0.62) | MAPTTP53LMNARAB9AALDH1A1 | |
| SCHEMBL13680930 | 0.81 | LMNA (0.55) | MAPTTP53LMNAPOLBKDM4E | |
| SCHEMBL13681346 | 0.81 | CDC25A (0.45) | GFERMAPTTP53LMNAPOLB | |
| SCHEMBL4284871 | 0.81 | GFER (0.75) | GFERMAPTTP53LMNAPOLB | |
| SCHEMBL13680945 | 0.80 | MEN1 (0.52) | MAPTTP53LMNARAB9AMEN1 | |
| SCHEMBL13680932 | 0.80 | KMT2A (0.47) | MAPTTP53LMNAPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |