Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200255 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2KDM4EHTTCYP1A2TSHR | |
| SCHEMBL19719534 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL16200075 | 0.81 | LMNA (0.41) | SMN1; SMN2KDM4EKMT2ALMNAPOLB | |
| SCHEMBL16200076 | 0.79 | CHRNB2 (0.45) | SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13457980 | 0.79 | PIK3R1 (0.42) | SMN1; SMN2NPSR1KDM4EALDH1A1HPGD | |
| SCHEMBL19719535 | 0.76 | SMN1; SMN2 (0.40) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL2256173 | 0.75 | HTT (0.44) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL4469941 | 0.70 | HTT (0.47) | SMN1; SMN2KDM4EALDH1A1HPGDHTT | |
| SCHEMBL12844552 | 0.69 | GAA (0.37) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL12776141 | 0.68 | GAA (0.39) | SMN1; SMN2KDM4EALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324216-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |