Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | BPTF | Q12830 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 6/20 | 0.37 |
| ▸ | NMT2 | O60551 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200255 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2PDE10AKDM4ECHRM4 | |
| SCHEMBL16200075 | 0.81 | LMNA (0.41) | NMT1HRH4SMN1; SMN2KDM4E | |
| SCHEMBL16200050 | 0.71 | PDE10A (0.42) | CHRNB2CHRNA4BPTFNMT1NMT2 | |
| SCHEMBL13184133 | 0.71 | SIGMAR1 (0.39) | NMT1SMN1; SMN2KDM4ECHRM2CHRM1 | |
| SCHEMBL25146239 | 0.68 | L3MBTL1 (0.46) | NMT1SMN1; SMN2KDM4EALDH1A1CHRM2 | |
| SCHEMBL14044159 | 0.68 | DRD2 (0.38) | SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13184164 | 0.67 | ADORA2A (0.36) | SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL14043926 | 0.67 | GABRA1 (0.41) | NMT1SMN1; SMN2PDE10AKDM4EALDH1A1 | |
| SCHEMBL23964360 | 0.67 | HTR2C (0.50) | CHRNB2CHRNA4PDE10AALDH1A1 | |
| SCHEMBL25695650 | 0.66 | CYP1A2 (0.48) | CHRNB2CHRNA4HRH4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |