Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200255 | 0.86 | SMN1; SMN2 (0.38) | LMNASMN1; SMN2C5AR1POLBKDM4E | |
| SCHEMBL16200076 | 0.81 | CHRNB2 (0.45) | HRH4SMN1; SMN2NMT1KDM4E | |
| SCHEMBL13683097 | 0.81 | SMN1; SMN2 (0.56) | LMNAKMT2ASMN1; SMN2POLBKDM4E | |
| SCHEMBL4488795 | 0.73 | HTT (0.47) | LMNAKMT2AHRH4SMN1; SMN2POLB | |
| SCHEMBL1086373 | 0.69 | — | — | |
| SCHEMBL14043925 | 0.67 | PKM (0.42) | LMNAKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL13683201 | 0.67 | KDM4E (0.33) | LMNAKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL1196939 | 0.66 | — | — | |
| SCHEMBL13184163 | 0.66 | CYP3A4 (0.38) | LMNAKMT2ASMN1; SMN2POLBKDM4E | |
| SCHEMBL13184164 | 0.66 | ADORA2A (0.36) | LMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |