Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.34 |
| ▸ | KDM5A | P29375 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.32 |
| ▸ | CCR9 | P51686 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14044112 | 0.84 | GRM2 (0.36) | GRM2PKMPLA2G2ARECQLALDH1A1 | |
| SCHEMBL16200404 | 0.80 | POLB (0.43) | GRM5PROKR1RECQLALDH1A1KDM4E | |
| SCHEMBL13683131 | 0.80 | GRM5 (0.42) | GRM5KDM5AKDM4CKDM5BPROKR1 | |
| SCHEMBL16200410 | 0.80 | NPSR1 (0.48) | GRM5ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL13184263 | 0.72 | BAZ2B (0.47) | KDM5AKDM4CKDM5BPROKR1ALDH1A1 | |
| SCHEMBL3356107 | 0.72 | UHRF1 (0.50) | KDM5AKDM4CKDM5BPROKR1ALDH1A1 | |
| SCHEMBL13184255 | 0.71 | MAPT (0.37) | ALDH1A1KDM4EGAAPOLBLMNA | |
| SCHEMBL13184401 | 0.71 | KDM4E (0.39) | GRM5KDM5AKDM4CKDM5BPROKR1 | |
| SCHEMBL14139367 | 0.70 | ALDH1A1 (0.34) | PROKR1RECQLALDH1A1GAAPOLB | |
| SCHEMBL18752578 | 0.68 | UHRF1 (0.42) | KDM5AKDM4CKDM5BPROKR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |