Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.35 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | CCR9 | P51686 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.33 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200404 | 0.83 | POLB (0.43) | GRM5PROKR1JMJD6POLBKDM4E | |
| SCHEMBL13683139 | 0.80 | GRM5 (0.35) | GRM5PROKR1JMJD6POLBKDM4E | |
| SCHEMBL13683137 | 0.79 | HDAC1 (0.43) | POLBKDM4EALDH1A1TTRHTR2A | |
| SCHEMBL13184257 | 0.78 | ALDH1A1 (0.44) | KDM4EALDH1A1GAAALPL | |
| SCHEMBL13184426 | 0.78 | GRM5 (0.37) | GRM5PROKR1JMJD6POLBKDM4E | |
| SCHEMBL13184263 | 0.75 | BAZ2B (0.47) | PROKR1JMJD6POLBKDM4EALDH1A1 | |
| SCHEMBL3356107 | 0.75 | UHRF1 (0.50) | PROKR1KDM4EALDH1A1CCR9KDM5A | |
| SCHEMBL13184401 | 0.74 | KDM4E (0.39) | GRM5PROKR1JMJD6POLBKDM4E | |
| SCHEMBL13683133 | 0.73 | KMT2A (0.45) | KDM4EALDH1A1GAAGSK3B | |
| SCHEMBL13184265 | 0.69 | KDM4E (0.39) | PROKR1JMJD6POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7435831-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435830-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |