Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.33 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683139 | 0.84 | GRM5 (0.35) | GRM2PKMALDH1A1KDM4EGAA | |
| SCHEMBL13184265 | 0.81 | KDM4E (0.39) | ALDH1A1KDM4EGAAPOLBAPOBEC3A | |
| SCHEMBL13184259 | 0.77 | KMT2A (0.39) | ALDH1A1KDM4EGAAL3MBTL1ELANE | |
| SCHEMBL13683129 | 0.73 | L3MBTL1 (0.37) | ALDH1A1KDM4EL3MBTL1ELANEHPGD | |
| SCHEMBL14043921 | 0.73 | MAPT (0.49) | ALDH1A1KDM4EPOLBJMJD6MAPT | |
| SCHEMBL3356107 | 0.69 | UHRF1 (0.50) | ALDH1A1KDM4EMAPT | |
| SCHEMBL14139367 | 0.68 | ALDH1A1 (0.34) | ALDH1A1GAARECQLPOLBHPGD | |
| SCHEMBL13683131 | 0.67 | GRM5 (0.42) | ALDH1A1KDM4EGAAPOLBAPOBEC3A | |
| SCHEMBL16200404 | 0.67 | POLB (0.43) | ALDH1A1KDM4EGAARECQLPOLB | |
| SCHEMBL18752578 | 0.65 | UHRF1 (0.42) | ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324216-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-7435831-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |