Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184407 | 0.82 | KDM4E (0.42) | KDM4EALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL13184408 | 0.80 | HDAC1 (0.40) | KDM4EALDH1A1SMN1; SMN2KMT2AHDAC1 | |
| SCHEMBL13683138 | 0.77 | POLB (0.43) | KDM4EALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL4400941 | 0.74 | HDAC1 (0.64) | KDM4EALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL16200409 | 0.71 | BAZ2B (0.47) | KDM4EALDH1A1KMT2ARAB9AHDAC1 | |
| SCHEMBL14043920 | 0.70 | HDAC1 (0.44) | KDM4EALDH1A1SMN1; SMN2KMT2AHDAC1 | |
| SCHEMBL2373838 | 0.69 | KDM4E (0.62) | KDM4EALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL3578797 | 0.69 | KDM4E (0.62) | KDM4EALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL13683137 | 0.69 | HDAC1 (0.43) | KDM4EALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL16200223 | 0.68 | SMN1; SMN2 (0.41) | ALDH1A1LMNASMN1; SMN2KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |