Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CCR9 | P51686 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184263 | 0.79 | BAZ2B (0.47) | BAZ2BHTR2AKDM4EKMT2ARAB9A | |
| SCHEMBL27787704 | 0.78 | BAZ2B (0.66) | BAZ2BHTR2AKDM4EKMT2ARAB9A | |
| SCHEMBL13184258 | 0.78 | BAZ2B (0.53) | BAZ2BKDM4EKMT2ARAB9AGAA | |
| SCHEMBL4400941 | 0.76 | HDAC1 (0.64) | HDAC1HDAC6KDM4EKMT2ARAB9A | |
| SCHEMBL13683138 | 0.74 | POLB (0.43) | HDAC1HDAC6KDM4EKMT2ARAB9A | |
| SCHEMBL13683137 | 0.74 | HDAC1 (0.43) | HDAC1HDAC6HTR2AKDM4EKMT2A | |
| SCHEMBL24307418 | 0.73 | ALDH1A1 (0.64) | HDAC1HDAC6KDM4ERAB9ANPC1 | |
| SCHEMBL13184261 | 0.71 | BAZ2B (0.49) | BAZ2BKDM4EKMT2ARAB9AGAA | |
| SCHEMBL13683179 | 0.71 | KDM4E (0.47) | HDAC1HDAC6KDM4EKMT2ARAB9A | |
| SCHEMBL12844484 | 0.70 | KMT2A (0.61) | HDAC1HDAC6KDM4EKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |