Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.37 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683138 | 0.83 | POLB (0.43) | HDAC1HDAC6POLBCYP1A2CYP3A4 | |
| SCHEMBL13184257 | 0.79 | ALDH1A1 (0.44) | CYP1A2CYP3A4CYP2C9HPGDMEN1 | |
| SCHEMBL13683131 | 0.79 | GRM5 (0.42) | POLBKDM4EALDH1A1HTR2AHTR2C | |
| SCHEMBL4400941 | 0.74 | HDAC1 (0.64) | HDAC1HDAC6POLBKCNQ3KCNQ2 | |
| SCHEMBL16200409 | 0.74 | BAZ2B (0.47) | HDAC1HDAC6POLBCYP1A2CYP3A4 | |
| SCHEMBL13683133 | 0.71 | KMT2A (0.45) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL8018191 | 0.70 | HDAC1 (0.60) | HDAC1HDAC6POLBCYP1A2CYP3A4 | |
| SCHEMBL13184253 | 0.69 | POLB (0.38) | POLBCYP1A2HPGDMEN1KMT2A | |
| SCHEMBL13683179 | 0.69 | KDM4E (0.47) | HDAC1HDAC6HPGDMEN1KMT2A | |
| SCHEMBL24307418 | 0.68 | ALDH1A1 (0.64) | HDAC1HDAC6HPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |