Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PER2 | O15055 | 16/20 | 0.40 |
| ▸ | CRY1 | Q16526 | 16/20 | 0.40 |
| ▸ | CRY2 | Q49AN0 | 16/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13127922 | 0.90 | PER2 (0.37) | PER2CRY1CRY2 | |
| SCHEMBL13792023 | 0.84 | PER2 (0.41) | PER2CRY1CRY2 | |
| SCHEMBL13622636 | 0.81 | CTSK (0.39) | PER2CRY1CRY2 | |
| SCHEMBL8282004 | 0.81 | CTSK (0.39) | PER2CRY1CRY2 | |
| SCHEMBL13791794 | 0.80 | CRY1 (0.38) | PER2CRY1CRY2 | |
| SCHEMBL8270963 | 0.78 | PER2 (0.41) | PER2CRY1CRY2 | |
| SCHEMBL13633039 | 0.78 | PER2 (0.44) | PER2CRY1CRY2 | |
| SCHEMBL13622674 | 0.77 | CTSK (0.41) | PER2CRY1CRY2 | |
| SCHEMBL8282033 | 0.77 | CTSK (0.41) | PER2CRY1CRY2 | |
| SCHEMBL8279628 | 0.75 | CRY1 (0.39) | PER2CRY1CRY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592419-B2 | Macrocyclic inhibitors of hepatitis C virus NS3-serine protease | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |