Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | TNKS | O95271 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12638572 | 0.74 | MEN1 (0.36) | KMT2AMEN1KDM4EMAPTTNKS | |
| SCHEMBL12638571 | 0.74 | MAPT (0.44) | KMT2AMEN1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL12638578 | 0.74 | CYP2C9 (0.37) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL12638535 | 0.71 | ALDH1A1 (0.41) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18472549 | 0.71 | KCNJ1 (0.41) | KMT2AMEN1SMN1; SMN2TNKSRAB9A | |
| SCHEMBL5656535 | 0.69 | KMT2A (0.44) | KMT2AMEN1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL1602588 | 0.69 | ADORA3 (0.54) | KMT2AMEN1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL19782842 | 0.69 | KCNJ1 (0.32) | KMT2AMEN1HPGDTSHR | |
| SCHEMBL1368505 | 0.68 | EGLN2 (0.46) | SMN1; SMN2L3MBTL1PBRM1ALDH1A1KDM4E | |
| SCHEMBL4508980 | 0.67 | KDM4E (0.35) | KMT2AMEN1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092230-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2018-07-11 | — | — | EP | claimed |
| US-9718808-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. (US) | 2017-08-01 | — | — | US | claimed |
| US-20170037037-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC | 2017-02-09 | — | — | US | claimed |
| EP-3092230-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2016-11-16 | — | — | EP | claimed |
| WO-2015103756-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2015-07-16 | — | — | WO | claimed |
| WO-2015105736-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2015-07-16 | — | — | WO | claimed |
| EP-0745154-B1 | MULTICOMPONENT SYSTEM FOR MODIFYING, DECOMPOSING OR BLEACHING LIGNIN, LIGNIN-CONTAINING MATERIALS OR SIMILAR SUBSTANCES AND METHOD OF USING THIS SYSTEM | LIGNOZYM GMBH (DE) | 1998-09-16 | — | — | EP | claimed |
| EP-0845026-A1 | MULTICOMPONENT SYSTEM FOR USE WITH DETERGENT SUBSTANCES | CALL, Hans-Peter Dr. (DE) | 1998-06-03 | — | — | EP | claimed |
| WO-1997048786-A1 | MULTICOMPONENT SYSTEM FOR USE WITH DETERGENT SUBSTANCES | CALL HANS PETER (DE) | 1997-12-24 | — | — | WO | claimed |
| EP-0717143-A1 | Multicomponents system for modifying decomposing or bleaching of lignin or materials containing it or similar components and the way to use it | Lignozym GmbH (DE) | 1996-06-19 | — | — | EP | claimed |
| US-12102631-B2 | Quinolylnitrones for the treatment and prevention of a cerebral stroke or ischaemia | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (ES) | 2024-10-01 | — | — | US | disclosed |
| EP-3863632-B1 | QUINOLYLNITRONE FOR USE IN THE TREATMENT AND PREVENTION OF A CEREBRAL STROKE OR ISCHAEMIA | ISQUAEMIA BIOTECH S L (ES) | 2023-06-07 | — | — | EP | disclosed |
| EP-3169672-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2020-04-29 | — | — | EP | disclosed |
| EP-3169673-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2020-04-29 | — | — | EP | disclosed |
| US-10208064-B2 | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME CORP. | 2019-02-19 | — | — | US | disclosed |
| US-3987196-A | FUNGISTATS | ELI LILLY AND COMPANY (US) | 1976-10-19 | — | — | US | disclosed |
| US-3979387-A | PROTECTION OF PLANTS FROM FOLIAR PATHOGENS | ELI LILLY AND COMPANY (US) | 1976-09-07 | — | — | US | disclosed |
| US-3974286-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1976-08-10 | — | — | US | disclosed |
| US-3891653-A | Substituted 4-5 dehydro-tetrazolo(1,5-a)quinolenes | LILLY CO ELI | 1975-06-24 | — | — | US | disclosed |
| US-3764681-A | CERTAIN TETRAZOLO-(1,5-A) QUINOLINE COMPOUNDS AS FUNGUS CONTROL AGENTS | LILLY CO ELI | 1973-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12102631-B2 | Quinolylnitrones for the treatment and prevention of a cerebral stroke or ischaemia | NLN, TXN2, TXN | KMT2A 4346/4885MEN1 2921/4885SMN1; SMN2 65/4885 |
| US-10208064-B2 | Inhibitors of the renal outer medullary potassium channel | KCNJ11, KCNJ1, KCNJ2 | KMT2A 1602/4885MEN1 336/4885SMN1; SMN2 1921/4885 |
| US-20170037037-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | KCNJ11, KCNJ1, KCNJ2 | KMT2A 1602/4885MEN1 336/4885SMN1; SMN2 1921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.