Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8279069 | 0.88 | HPGD (0.68) | HPGDCYP1A2CYP2C19RAB9AKDR | |
| SCHEMBL28729711 | 0.84 | CYP1A2 (0.53) | HPGDCYP1A2CYP2C19RAB9APOLB | |
| SCHEMBL11594362 | 0.79 | CYP1A2 (0.68) | HPGDCYP1A2CYP2C19RAB9AKDR | |
| SCHEMBL13690060 | 0.78 | PDK1 (0.50) | POLBMEN1KMT2AHTTLMNA | |
| SCHEMBL11155741 | 0.75 | PBRM1 (0.58) | HPGDCYP1A2CYP2C19RAB9APOLB | |
| SCHEMBL20275216 | 0.75 | ALDH1A1 (0.46) | HPGDCYP1A2CYP2C19POLBALDH1A1 | |
| SCHEMBL31125356 | 0.75 | ALDH1A1 (0.41) | HPGDCYP1A2CYP2C19POLBALDH1A1 | |
| SCHEMBL9273411 | 0.75 | ALDH1A1 (0.41) | HPGDCYP1A2CYP2C19POLBALDH1A1 | |
| SCHEMBL9833874 | 0.74 | CYP1A2 (0.77) | HPGDCYP1A2CYP2C19RAB9AKDR | |
| SCHEMBL1514283 | 0.74 | HPGD (0.77) | HPGDCYP1A2CYP2C19RAB9AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595399-B2 | Tyrosine derivatives | GENENTECH, INC. (US) | 2009-09-29 | — | — | US | disclosed |