Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982606 | 0.83 | GPR119 (0.50) | GPR119NPBWR1MCHR1PRMT5WDR77 | |
| SCHEMBL29495589 | 0.83 | GPR119 (0.50) | GPR119NPBWR1MCHR1PRMT5WDR77 | |
| SCHEMBL4048177 | 0.83 | MGLL (0.36) | — | |
| SCHEMBL5079976 | 0.81 | GPR119 (0.50) | GPR119PRMT5WDR77 | |
| SCHEMBL5267887 | 0.80 | GPR119 (0.68) | GPR119NPBWR1MCHR1 | |
| SCHEMBL4048769 | 0.80 | JAK2 (0.48) | GPR119 | |
| SCHEMBL18280155 | 0.80 | GPR119 (0.52) | GPR119 | |
| SCHEMBL13690547 | 0.78 | GPR119 (0.57) | GPR119 | |
| SCHEMBL23311681 | 0.78 | GPR119 (0.51) | GPR119HPGD | |
| SCHEMBL23080408 | 0.77 | GPR119 (0.50) | GPR119PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |