Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048446 | 0.85 | GPR119 (0.43) | GPR119 | |
| SCHEMBL3979657 | 0.84 | JAK2 (0.54) | JAK2JAK1GPR119MEN1KMT2A | |
| SCHEMBL13690493 | 0.82 | GPR119 (0.54) | GPR119 | |
| SCHEMBL5079865 | 0.82 | GPR119 (0.48) | JAK2JAK1GPR119 | |
| SCHEMBL13690490 | 0.80 | GPR119 (0.48) | GPR119 | |
| SCHEMBL13690499 | 0.80 | GPR119 (0.57) | GPR119 | |
| SCHEMBL13690325 | 0.79 | FAAH (0.33) | — | |
| SCHEMBL13690774 | 0.78 | GPR119 (0.47) | GPR119 | |
| SCHEMBL13690482 | 0.78 | GPR119 (0.63) | GPR119 | |
| SCHEMBL15465384 | 0.77 | GPR119 (0.60) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |