Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Coformycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADA known ✓ | P00813 | 4/20 | 0.68 |
| ▸ | AMPD3 | Q01432 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HBB | P68871 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Coformycin SCHEMBL8373037 | 1.00 | ADA (0.68) | ADAAMPD3ALDH1A1TP53HTT | |
| Coformycin SCHEMBL442534 | 1.00 | ADA (0.68) | ADAAMPD3ALDH1A1TP53HTT | |
| Coformycin SCHEMBL13697294 | 1.00 | ADA (0.68) | ADAAMPD3ALDH1A1TP53HTT | |
| Coformycin SCHEMBL7796895 | 1.00 | ADA (0.68) | ADAAMPD3ALDH1A1TP53HTT | |
| SCHEMBL10792647 | 0.90 | ADA (0.55) | ADAAMPD3ALDH1A1TP53HTT | |
| SCHEMBL8371414 | 0.90 | ADA (0.55) | ADAAMPD3ALDH1A1TP53HTT | |
| SCHEMBL7790217 | 0.90 | ADA (0.55) | ADAAMPD3ALDH1A1TP53HTT | |
| SCHEMBL10705678 | 0.90 | ADA (0.55) | ADAAMPD3ALDH1A1TP53HTT | |
| SCHEMBL13111762 | 0.90 | ADA (0.58) | ADAAMPD3ALDH1A1TP53HTT | |
| SCHEMBL13697498 | 0.87 | ADA (0.53) | ADAAMPD3ALDH1A1TP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227532-A1 | Analogues of Coformycin and Their Use for Treating Protozoan Parasite Infections | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227532-A1 | Analogues of Coformycin and Their Use for Treating Protozoan Parasite Infections | PDF, PPIF, MT-CO1 | ADA 2697/4885AMPD3 229/4885ALDH1A1 2249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.