Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154510 | 0.89 | CYP11B1 (0.52) | CYP11B1CYP11B2ALDH1A1MAPTGAA | |
| SCHEMBL11442963 | 0.81 | ALDH1A1 (0.37) | ALDH1A1MAPTGAAHSD17B10HTT | |
| SCHEMBL2616330 | 0.81 | CYP11B1 (0.43) | CYP11B1CYP11B2ALDH1A1GAANOTUM | |
| SCHEMBL28570739 | 0.81 | CYP11B1 (0.43) | CYP11B1CYP11B2ALDH1A1MAPTGAA | |
| SCHEMBL11431097 | 0.79 | ALDH1A1 (0.59) | ALDH1A1MAPTGAAHSD17B10HTT | |
| SCHEMBL31371786 | 0.79 | DRD2 (0.45) | CYP11B1CYP11B2NOTUMPIK3CBPIK3CG | |
| SCHEMBL13591314 | 0.78 | NISCH (0.42) | CYP11B1CYP11B2ALDH1A1MAPTGAA | |
| SCHEMBL5022145 | 0.77 | KMT2A (0.52) | CYP11B1CYP11B2ALDH1A1MAPTGAA | |
| SCHEMBL9228795 | 0.77 | NOTUM (0.49) | CYP11B1CYP11B2NOTUMHTTKMT2A | |
| SCHEMBL28501007 | 0.76 | MAPT (0.45) | ALDH1A1MAPTGAAHSD17B10NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3097078-B1 | PYRIDINES AND PYRIMIDINES AND USE THEREOF | PURDUE PHARMA LP (US) | 2022-05-25 | — | — | EP | disclosed |
| US-20170008882-A1 | PYRIDINES AND PYRIMIDINES AND USE THEREOF | PURDUE PHARMA L.P. | 2017-01-12 | — | — | US | disclosed |
| US-20090233910-A1 | Npy antagonists, preparation and uses | CEREP (FR) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233910-A1 | Npy antagonists, preparation and uses | NPY1R, NPY5R, NPY2R | CYP11B1 572/4885CYP11B2 535/4885ALDH1A1 4542/4885 |
| US-20170008882-A1 | PYRIDINES AND PYRIMIDINES AND USE THEREOF | CACNA1A, P2RX3, P2RX6 | CYP11B1 3029/4885CYP11B2 2752/4885ALDH1A1 658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.