Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.55 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | S100B | P04271 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11675977 | 0.80 | SERPINE1 (0.52) | SERPINE1ACMSDHDAC1HDAC2HDAC3 | |
| SCHEMBL417671 | 0.79 | SERPINE1 (0.59) | SERPINE1ACMSDHDAC1HDAC2HDAC3 | |
| SCHEMBL31554955 | 0.79 | SERPINE1 (0.59) | SERPINE1ACMSDHDAC1HDAC2HDAC3 | |
| SCHEMBL13701695 | 0.75 | HDAC8 (0.64) | LMNASMN1; SMN2S100B | |
| SCHEMBL21249304 | 0.74 | LMNA (0.58) | LMNANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL13701654 | 0.74 | RXRA (0.59) | LMNANPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL13701631 | 0.74 | HDAC8 (0.54) | LMNANPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL6051820 | 0.74 | ACMSD (0.56) | SERPINE1ACMSDLMNAALDH1A1HPGD | |
| SCHEMBL13701677 | 0.73 | KDM4E (0.50) | LMNANPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL13701672 | 0.73 | PLAU (0.48) | LMNACYP2C19S100B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | FLECK ROMAN WOLFGANG | 2009-09-10 | — | — | US | disclosed |
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | FLECK ROMAN WOLFGANG | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | EPHX1, EPHX2, EPX | SERPINE1 228/4885ACMSD 3096/4885HDAC1 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.