Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.50 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8541406 | 0.84 | NPC1 (0.64) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10197594 | 0.83 | LMNA (0.58) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19605409 | 0.82 | HDAC8 (0.63) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8387420 | 0.82 | MEN1 (0.59) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13342147 | 0.81 | HDAC8 (0.67) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21249304 | 0.81 | LMNA (0.58) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13701782 | 0.81 | NPSR1 (0.60) | LMNANPC1RAB9AKMT2AHSD17B10 | |
| SCHEMBL13701706 | 0.80 | TAS1R3 (0.56) | LMNAALDH1A1NPC1RAB9AKAT6A | |
| SCHEMBL12133228 | 0.80 | LMNA (0.82) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30184136 | 0.79 | NPC1 (0.56) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | FLECK ROMAN WOLFGANG | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227588-A1 | Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors | EPHX1, EPHX2, EPX | LMNA 1843/4885ALDH1A1 376/4885NPC1 1477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.