Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4154525 | 0.99 | ALDH1A1 (0.67) | ALDH1A1MAPTHPGDLMNAGAA | |
| SCHEMBL3769768 | 0.85 | TDP1 (0.69) | ALDH1A1MAPTHPGDLMNAGAA | |
| SCHEMBL134682 | 0.82 | TDP1 (0.65) | ALDH1A1MAPTHPGDLMNAGAA | |
| SCHEMBL3773567 | 0.81 | ALDH1A1 (0.73) | ALDH1A1MAPTHPGDLMNAGAA | |
| SCHEMBL134129 | 0.81 | ALDH1A1 (0.73) | ALDH1A1MAPTHPGDLMNAGAA | |
| SCHEMBL140059 | 0.81 | MAPT (1.00) | ALDH1A1MAPTHPGDLMNAGAA | |
| SCHEMBL1637546 | 0.80 | ALDH1A1 (1.00) | ALDH1A1MAPTHPGDLMNAGAA | |
| SCHEMBL4144407 | 0.80 | ALDH1A1 (0.71) | ALDH1A1MAPTHPGDLMNAGAA | |
| SCHEMBL4147685 | 0.80 | ANO1 (0.64) | MAPTTP53 | |
| SCHEMBL135664 | 0.79 | ALDH1A1 (0.73) | ALDH1A1MAPTHPGDLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317709-A1 | SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR COMPOUNDS | UNIVERSITEIT LEIDEN | 2010-12-16 | — | — | US | claimed |
| EP-2430029-B1 | THIENO[2,3-B]PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | UNIV LEUVEN KATH (BE) | 2018-01-10 | — | — | EP | disclosed |
| US-9499563-B2 | Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2016-11-22 | — | — | US | disclosed |
| US-20140296272-A1 | THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | CISTIM LEUVEN VZW (BE) | 2014-10-02 | — | — | US | disclosed |
| US-8785638-B2 | Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2014-07-22 | — | — | US | disclosed |
| EP-2430029-A1 | THIENO [2, 3-B]PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | Katholieke Universiteit Leuven (BE) | 2012-03-21 | — | — | EP | disclosed |
| US-20120059028-A1 | THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2012-03-08 | — | — | US | disclosed |
| US-20100317709-A1 | SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR COMPOUNDS | UNIVERSITEIT LEIDEN | 2010-12-16 | — | — | US | disclosed |
| WO-2010130842-A1 | THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2010-11-18 | — | — | WO | disclosed |
| EP-2214663-A1 | SPHINGOSINE- 1- PHOSPHATE (S1P) RECEPTOR COMPOUNDS | Universiteit Leiden (NL) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009063301-A1 | SPHINGOSINE- 1- PHOSPHATE (S1P) RECEPTOR COMPOUNDS | UNIVERSITEIT LEIDEN (NL) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296272-A1 | THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | TYMP, DUT, MAVS | ALDH1A1 1925/4885MAPT 2061/4885HPGD 466/4885 |
| US-20100317709-A1 | SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR COMPOUNDS | S1PR3, S1PR1, S1PR5 | ALDH1A1 4570/4885MAPT 4166/4885HPGD 3221/4885 |
| US-20120059028-A1 | THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | TYMP, DUT, MAVS | ALDH1A1 1925/4885MAPT 2061/4885HPGD 466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.