Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 4/20 | 0.35 |
| ▸ | HTR7 | P34969 | 3/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 4/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.32 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13708537 | 0.85 | FFAR1 (0.37) | HTR2BHTR7KMT2AALDH1A1 | |
| SCHEMBL4475021 | 0.84 | MDM2 (0.39) | PARP1NOD2NOD1PARP2MEN1 | |
| SCHEMBL4470947 | 0.81 | PARP1 (0.34) | PARP1NOD2NOD1PARP2MEN1 | |
| SCHEMBL13708578 | 0.81 | BACE1 (0.35) | PARP1SLC9A1BACE1KMT2ALMNA | |
| SCHEMBL28746674 | 0.81 | IDO1 (0.40) | NOD2NOD1MEN1KMT2AHSD17B10 | |
| SCHEMBL13708577 | 0.80 | NPC1 (0.37) | SLC9A1BACE1MEN1KMT2ALMNA | |
| SCHEMBL13708568 | 0.78 | HTR5A (0.33) | PARP1SLC9A1 | |
| SCHEMBL13708554 | 0.78 | MDM2 (0.37) | HTR2BHTR7SLC9A1BACE1MDM2 | |
| SCHEMBL13708556 | 0.78 | SLC9A1 (0.32) | SLC9A1MEN1KMT2AHTR6 | |
| SCHEMBL13708565 | 0.78 | TRPA1 (0.39) | HTR2BHTR7PARP1SLC9A1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589117-B2 | Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-09-15 | — | — | US | disclosed |
| US-7589117-B2 | Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-09-15 | — | — | US | disclosed |