Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLA1 | P09884 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29120496 | 0.85 | KDM4E (0.58) | ALDH1A1KDM4ECDK2RXFP1PAK1 | |
| SCHEMBL11802315 | 0.84 | ALDH1A1 (0.57) | ALDH1A1KDM4ECDK2RXFP1PAK1 | |
| SCHEMBL28715732 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KDM4ECDK2RXFP1PAK1 | |
| SCHEMBL7592034 | 0.80 | ALDH1A1 (0.49) | ALDH1A1KDM4ECDK2RXFP1PAK1 | |
| SCHEMBL29120493 | 0.80 | KDM4E (0.49) | ALDH1A1KDM4ECDK2RXFP1PAK1 | |
| SCHEMBL30729987 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4ECDK2RXFP1PAK1 | |
| SCHEMBL27773229 | 0.77 | ALDH1A1 (0.49) | ALDH1A1KDM4ECDK2RXFP1PAK1 | |
| SCHEMBL16802769 | 0.75 | MEN1 (0.52) | ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL27535767 | 0.75 | XDH (0.47) | ALDH1A1KDM4ECDK2RXFP1PAK1 | |
| SCHEMBL27469940 | 0.74 | CDK2 (0.51) | ALDH1A1KDM4ECDK2RXFP1PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1491201-B1 | Methods of reducing toxicity of 5-fluorouracil with acylated pyrimidine nucleosides | WELLSTAT THERAPEUTICS CORP (US) | 2006-03-22 | — | — | EP | claimed |
| JP-2003506375-A | — | — | 2003-02-18 | — | — | JP | claimed |
| EP-1200435-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | Novartis AG (CH) | 2002-05-02 | — | — | EP | claimed |
| WO-2001009134-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2001-02-08 | — | — | WO | claimed |
| US-20250333418-A1 | PURINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | NOVO NORDISK AS (DK) | 2025-10-30 | — | — | US | disclosed |
| CN-111123643-B | Protective composition and method for forming photoresist pattern | 台湾积体电路制造股份有限公司 | 2023-11-07 | — | — | CN | disclosed |
| EP-3452477-B1 | ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | B C I PHARMA (BE) | 2023-09-13 | — | — | EP | disclosed |
| CN-115151642-A | Antisense nucleic acids capable of exon skipping | 日本新药株式会社 | 2022-10-04 | — | — | CN | disclosed |
| US-11236093-B2 | Adenine derivatives as protein kinase inhibitors | B.C.I. PHARMA (BE) | 2022-02-01 | — | — | US | disclosed |
| US-20190127379-A1 | ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | B.C.I. PHARMA (BE) | 2019-05-02 | — | — | US | disclosed |
| EP-3452477-A1 | ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | B.C.I. Pharma (BE) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017191297-A1 | ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | BCI PHARMA (FR) | 2017-11-09 | — | — | WO | disclosed |
| US-20020028476-A1 | Method of determining thiopurine methyltransferase activity | PROMETHEUS LABORATORIES, INC. | 2002-03-07 | — | — | US | disclosed |
| WO-2001090308-A2 | METHOD OF DETERMINING THIOPURINE METHYLTRANSFERASE ACTIVITY | PROMETHEUS LABORATORIES, INC. (US) | 2001-11-29 | — | — | WO | disclosed |
| US-6319682-B1 | DETECTING CHLORIDE CHANNEL MODULATORS; MIX CELL AND HYDROGEN ION CONCENTRATION ADJUSTER, EVALUATE AND RECORD CELL ACTIVITY, INCUBATE CELLS WITH MODULATOR AND EVALUATE CELL ACTIVITY, COMPARE TO CONTROL | CYTOSCAN SCIENCES, L.L.C. | 2001-11-20 | — | — | US | disclosed |
| EP-0533744-A1 | HETEROCYCLIC ANTHRACYCLIONE AND ANTHRACYCLINE ANALOGS | BIOCHEM PHARMA INC. (CA) | 1993-03-31 | — | — | EP | disclosed |
| US-4622324-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVES | DR. WILLMAR SCHWABE GMBH & CO. (DE) | 1986-11-11 | — | — | US | disclosed |
| EP-0044928-B1 | 1,4;3,6-DIANHYDRO-HEXITE-NITRATE SUBSTITUTED BY PURINE BASES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL COMPOSITIONS | Dr. Willmar Schwabe GmbH & Co. (DE) | 1985-03-13 | — | — | EP | disclosed |
| US-4479951-A | CORONARY DIESASE | DR. WILLMAR SCHWABE GMBH & CO. (DE) | 1984-10-30 | — | — | US | disclosed |
| EP-0044928-A1 | 1,4;3,6-Dianhydro-hexite-nitrate substituted by purine bases, process for their preparation and their pharmaceutical compositions | Dr. Willmar Schwabe GmbH & Co. (DE) | 1982-02-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11236093-B2 | Adenine derivatives as protein kinase inhibitors | ADK, TNNI3K, TNK2 | ALDH1A1 3196/4885KDM4E 1276/4885CDK2 62/4885 |
| US-20190127379-A1 | ADENINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ADK, TNNI3K, TNK2 | ALDH1A1 3196/4885KDM4E 1276/4885CDK2 62/4885 |
| US-20250333418-A1 | PURINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | CNR1, CNR2, P2RY1 | ALDH1A1 1291/4885KDM4E 3616/4885CDK2 1294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.