Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.87 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.62 |
| ▸ | HTR3B | O95264 | 1/20 | 0.62 |
| ▸ | HTR3A | P46098 | 1/20 | 0.62 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.62 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 3/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4519830 | 0.93 | KCNH2 (1.00) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL13711976 | 0.87 | KCNH2 (0.88) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL3153996 | 0.82 | HTR3E (0.66) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4521524 | 0.81 | KCNH2 (1.00) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL25695217 | 0.80 | HTR3E (0.67) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL1907440 | 0.79 | KCNH2 (0.64) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9041083 | 0.79 | KCNH2 (0.80) | KCNH2HTR1AHTR2ADRD3DRD2 | |
| SCHEMBL6525545 | 0.78 | KCNH2 (0.71) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL2127461 | 0.77 | HTR3A (1.00) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL6526782 | 0.77 | KCNH2 (0.70) | KCNH2HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090238761-A1 | Novel Aryl Piperazine Derivatives With Medical Utility | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090238761-A1 | Novel Aryl Piperazine Derivatives With Medical Utility | HTR2C, HTR2A, DRD2 | KCNH2 769/4885HTR3E 9/4885HTR3B 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.