Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.66 |
| ▸ | HTR3B | O95264 | 3/20 | 0.66 |
| ▸ | HTR3A | P46098 | 3/20 | 0.66 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.66 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | HTR1A | P08908 | 4/20 | 0.53 |
| ▸ | HTR2A | P28223 | 4/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6525545 | 0.90 | KCNH2 (0.71) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL6526782 | 0.88 | KCNH2 (0.70) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL25695217 | 0.82 | HTR3E (0.67) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL13711981 | 0.82 | KCNH2 (0.87) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL14761172 | 0.81 | DRD2 (0.50) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL6525544 | 0.80 | KCNH2 (0.63) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2127461 | 0.80 | HTR3A (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL4519830 | 0.79 | KCNH2 (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL13711976 | 0.79 | KCNH2 (0.88) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Ammonia Solution, Strong SCHEMBL28472249 | 0.78 | HTR3A (0.96) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074083-B1 | NEW SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT (HU) | 2013-06-19 | — | — | EP | disclosed |
| CN-101528681-B | New sulfonamide derivatives as bradykinin antagonists | RITCHER GEDEON NYRT | 2013-01-30 | — | — | CN | disclosed |
| US-20100075978-A1 | SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT. (HU) | 2010-03-25 | — | — | US | disclosed |
| CN-101528681-A | New sulfonamide derivatives as bradykinin antagonists | RITCHER GEDEON NYRT (HU) | 2009-09-09 | — | — | CN | disclosed |
| EP-2074083-A1 | NEW SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | Richter Gedeon NYRT (HU) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008050168-A1 | NEW SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT. (HU) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075978-A1 | SULFONAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | BDKRB1, BDKRB2, TRPV1 | HTR3E 834/4885HTR3B 882/4885HTR3A 911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.