Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 8/20 | 0.55 |
| ▸ | DRD2 | P14416 | 5/20 | 0.55 |
| ▸ | HTR2A | P28223 | 4/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.55 |
| ▸ | HTR7 | P34969 | 3/20 | 0.54 |
| ▸ | DRD1 | P21728 | 2/20 | 0.54 |
| ▸ | HTR3A | P46098 | 2/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13711984 | 0.86 | KCNH2 (0.62) | DRD3KCNH2HTR1ADRD2HTR2A | |
| SCHEMBL9283836 | 0.83 | DRD2 (0.59) | DRD3HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL9287528 | 0.83 | HTR1A (0.55) | DRD3HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL240727 | 0.83 | HTR1A (0.55) | DRD3HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL8149406 | 0.82 | DRD2 (0.61) | DRD3KCNH2HTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL9639052 | 0.81 | DRD2 (0.57) | DRD3HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL9041083 | 0.81 | KCNH2 (0.80) | DRD3KCNH2HTR1ADRD2HTR2A | |
| SCHEMBL9643856 | 0.81 | HTR1A (0.74) | DRD3HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL9373235 | 0.81 | SIGMAR1 (0.63) | DRD3HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL5187310 | 0.80 | HTR1A (0.60) | DRD3KCNH2HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090238761-A1 | Novel Aryl Piperazine Derivatives With Medical Utility | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090238761-A1 | Novel Aryl Piperazine Derivatives With Medical Utility | HTR2C, HTR2A, DRD2 | DRD3 10/4885HRH3 331/4885KCNH2 769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.