Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.61 |
| ▸ | DRD3 | P35462 | 9/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8156167 | 0.83 | DRD2 (0.55) | DRD2DRD3KCNH2HTR2ADRD4 | |
| SCHEMBL8142915 | 0.83 | DRD2 (0.57) | DRD2DRD3KCNH2HTR2ADRD4 | |
| SCHEMBL8156679 | 0.83 | DRD2 (0.55) | DRD2DRD3KCNH2HTR2ADRD4 | |
| SCHEMBL8142907 | 0.83 | DRD2 (0.55) | DRD2DRD3HTR1A | |
| SCHEMBL8148960 | 0.83 | DRD2 (0.55) | DRD2DRD3KCNH2HTR1AHTR2A | |
| SCHEMBL13711982 | 0.82 | DRD3 (0.60) | DRD2DRD3KCNH2HTR1AHTR7 | |
| SCHEMBL8156689 | 0.82 | DRD2 (0.53) | DRD2DRD3KCNH2HTR2ADRD4 | |
| SCHEMBL8150800 | 0.79 | HTR1A (0.57) | HTR1A | |
| SCHEMBL8305949 | 0.78 | DRD2 (0.49) | DRD2DRD3KCNH2HTR2ADRD4 | |
| SCHEMBL8155543 | 0.78 | DRD2 (0.54) | DRD2DRD3KCNH2HTR2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673375-B1 | FUSED BENZO COMPOUNDS | LUNDBECK & CO AS H (DK) | 1999-02-24 | — | — | EP | claimed |
| US-6140331-A | FOR TREATING ANXIETY DISORDERS, DEPRESSION, PSYCHOSIS, IMPULSE CONTROL DISORDERS, ALCOHOL ABUSE, ISCHAEMIC DISEASES, CARDIOVASCULAR DISORDERS, SIDE EFFECTS INDUCED BY CONVENTIONAL ANTIPSYCHOTIC AGENTS AND SENILE DEMENTIA | H. LUNDBECK A/S (DK) | 2000-10-31 | — | — | US | disclosed |
| EP-0673375-B1 | FUSED BENZO COMPOUNDS | LUNDBECK & CO AS H (DK) | 1999-02-24 | — | — | EP | disclosed |
| EP-0673375-A1 | FUSED BENZO COMPOUNDS | H. LUNDBECK A/S (DK) | 1995-09-27 | — | — | EP | disclosed |
| WO-1994013659-A1 | FUSED BENZO COMPOUNDS | H. LUNDBECK A/S (DK) | 1994-06-23 | — | — | WO | disclosed |