Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PPM1B | O75688 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14565673 | 0.97 | TAS1R3 (0.49) | TAS1R3TAS1R1JAK1ALDH1A1PPM1B | |
| SCHEMBL4495502 | 0.84 | JAK1 (0.46) | TAS1R3TAS1R1JAK1ALDH1A1PPM1B | |
| SCHEMBL4489974 | 0.83 | TAS1R3 (0.43) | TAS1R3TAS1R1JAK1ALDH1A1PPM1B | |
| SCHEMBL8441969 | 0.83 | TAS1R3 (0.43) | TAS1R3TAS1R1JAK1ALDH1A1PPM1B | |
| SCHEMBL13712967 | 0.82 | CHRM2 (0.47) | TAS1R3TAS1R1PSEN1PSEN2APH1B | |
| SCHEMBL13712966 | 0.82 | CHRM2 (0.47) | TAS1R3TAS1R1PSEN1PSEN2APH1B | |
| SCHEMBL14534581 | 0.81 | TAS1R3 (0.48) | TAS1R3TAS1R1JAK1ALDH1A1PSEN1 | |
| SCHEMBL5656187 | 0.81 | PSEN1 (0.55) | TAS1R3TAS1R1JAK1ALDH1A1PSEN1 | |
| SCHEMBL4480695 | 0.81 | TAS1R3 (0.43) | TAS1R3TAS1R1JAK1ALDH1A1CTSB | |
| SCHEMBL30593660 | 0.81 | THRB (0.43) | TAS1R3TAS1R1JAK1ALDH1A1PPM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582626-B2 | 5,6-dihydro-1H-pyridin-2-one compounds | ANADYS PHARMACEUTICALS, INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-20090111798-A1 | 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS | ANADYS PHARMACEUTICALS, INC. | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111798-A1 | 5,6-DIHYDRO-1H-PYRIDIN-2-ONE COMPOUNDS | HAVCR2, PYGL, HCCS | TAS1R3 4286/4885TAS1R1 4108/4885JAK1 1450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.