Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3854698 | 0.91 | HPRT1 (0.40) | HSP90AA1HSP90AB1CDK1CCNB1CCNE1 | |
| SCHEMBL13714795 | 0.89 | NT5E (0.33) | HSP90AA1HSP90AB1CDK1CCNB1CCNE1 | |
| SCHEMBL13714875 | 0.88 | FDPS (0.34) | — | |
| SCHEMBL13714861 | 0.85 | FAP (0.41) | — | |
| SCHEMBL6005011 | 0.84 | NT5E (0.34) | HSP90AA1HSP90AB1CDK1CCNB1CCNE1 | |
| SCHEMBL3857077 | 0.79 | FDPS (0.40) | HPRT1 | |
| SCHEMBL13714868 | 0.78 | — | — | |
| SCHEMBL3852262 | 0.77 | FGFR1 (0.32) | — | |
| SCHEMBL13715042 | 0.77 | ABCB11 (0.32) | — | |
| SCHEMBL13714767 | 0.75 | HSP90AB1 (0.43) | HSP90AA1HSP90AB1HDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579332-B2 | Nucleobase phosphonate analogs for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2009-08-25 | — | — | US | disclosed |