Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.54 |
| ▸ | GCK | P35557 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | ARAF | P10398 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13743935 | 0.89 | BRAF (0.55) | BRAFHDAC1GCKSCN9ARAF1 | |
| SCHEMBL13715199 | 0.85 | BRAF (0.58) | BRAFHDAC1GCKSCN9ARAF1 | |
| SCHEMBL13715181 | 0.84 | MEN1 (0.43) | BRAFHDAC1GCKMEN1GAA | |
| Hydrochloric Acid SCHEMBL2454106 | 0.76 | BRAF (0.57) | BRAFHDAC1GCKGAARAF1 | |
| SCHEMBL5431408 | 0.75 | TACR3 (0.54) | TAS1R3TAS1R1TACR3SMN1; SMN2THRB | |
| SCHEMBL12846985 | 0.75 | BRAF (0.56) | BRAFHDAC1GCKMEN1KMT2A | |
| SCHEMBL4275464 | 0.75 | GCK (0.60) | BRAFHDAC1GCKRAF1ARAF | |
| SCHEMBL31160842 | 0.75 | KEAP1 (0.49) | BRAFHDAC1GCKMEN1KMT2A | |
| SCHEMBL13743629 | 0.74 | NPSR1 (0.43) | BRAFHDAC1GCKMEN1KMT2A | |
| SCHEMBL12789530 | 0.74 | BRAF (0.61) | BRAFHDAC1GCKRAF1ARAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572783-B2 | Obesity; N-(1-benzyl-piperidin-4-yl)-2-(2,5-dioxo-7-phenoxy-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl)-3-methyl-butyramide; modulators of ghrelin receptor (GHSR) | AMGEN INC. (US) | 2009-08-11 | — | — | US | disclosed |