Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.58 |
| ▸ | GCK | P35557 | 5/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.45 |
| ▸ | ARAF | P10398 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13743935 | 0.86 | BRAF (0.55) | BRAFHDAC1GCKHDAC3HDAC4 | |
| SCHEMBL13715264 | 0.85 | BRAF (0.54) | BRAFHDAC1GCKHDAC3HDAC4 | |
| SCHEMBL13715272 | 0.83 | SMN1; SMN2 (0.44) | BRAFHDAC1GCKPTGER4PTGER2 | |
| SCHEMBL4275464 | 0.79 | GCK (0.60) | BRAFHDAC1GCKHDAC3HDAC4 | |
| SCHEMBL13715394 | 0.78 | ALDH1A1 (0.42) | BRAFHDAC1GCKSCN9APTGER4 | |
| SCHEMBL12789530 | 0.78 | BRAF (0.61) | BRAFHDAC1GCKHDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL2454106 | 0.77 | BRAF (0.57) | BRAFHDAC1GCKHDAC3HDAC4 | |
| SCHEMBL2426327 | 0.76 | KEAP1 (0.66) | BRAFHDAC1GCKHDAC3HDAC4 | |
| SCHEMBL12846985 | 0.76 | BRAF (0.56) | BRAFHDAC1GCKHDAC3HDAC4 | |
| SCHEMBL2643497 | 0.73 | GCK (1.00) | BRAFHDAC1GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572783-B2 | Obesity; N-(1-benzyl-piperidin-4-yl)-2-(2,5-dioxo-7-phenoxy-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl)-3-methyl-butyramide; modulators of ghrelin receptor (GHSR) | AMGEN INC. (US) | 2009-08-11 | — | — | US | disclosed |