Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.56 |
| ▸ | GCK | P35557 | 4/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.45 |
| ▸ | ARAF | P10398 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2454106 | 0.84 | BRAF (0.57) | BRAFHDAC1GCKRAF1ARAF | |
| SCHEMBL12789530 | 0.82 | BRAF (0.61) | BRAFHDAC1GCKRAF1ARAF | |
| SCHEMBL2426327 | 0.80 | KEAP1 (0.66) | BRAFHDAC1GCKRAF1ARAF | |
| SCHEMBL22407007 | 0.80 | PPARA (0.43) | BRAFHDAC1SCN9A | |
| SCHEMBL1026182 | 0.80 | BRAF (0.59) | BRAFHDAC1GCKRAF1ARAF | |
| SCHEMBL12846984 | 0.79 | TDP1 (0.47) | BRAFHDAC1GCKMEN1MAPT | |
| SCHEMBL16595406 | 0.77 | CES2 (0.52) | BRAFHDAC1KDM4EMEN1NPC1 | |
| SCHEMBL13715199 | 0.76 | BRAF (0.58) | BRAFHDAC1GCKRAF1ARAF | |
| SCHEMBL13715264 | 0.75 | BRAF (0.54) | BRAFHDAC1GCKRAF1ARAF | |
| SCHEMBL13743935 | 0.73 | BRAF (0.55) | BRAFHDAC1GCKRAF1ARAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME CORP. | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | GPR119, GPR39, GPR65 | BRAF 4467/4885HDAC1 612/4885GCK 525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.