Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.61 |
| ▸ | GCK | P35557 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | ARAF | P10398 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2426327 | 0.85 | KEAP1 (0.66) | BRAFHDAC1GCKHDAC3HDAC4 | |
| SCHEMBL9368064 | 0.83 | MAOB (0.50) | BRAFHDAC1GCKCYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL2454106 | 0.83 | BRAF (0.57) | BRAFHDAC1GCKHDAC3HDAC4 | |
| SCHEMBL12846985 | 0.82 | BRAF (0.56) | BRAFHDAC1GCKHDAC3HDAC4 | |
| SCHEMBL29467969 | 0.81 | KEAP1 (0.68) | BRAFHDAC1HDAC3HDAC2KEAP1 | |
| SCHEMBL9665493 | 0.81 | KEAP1 (0.68) | BRAFHDAC1HDAC3HDAC2KEAP1 | |
| SCHEMBL6149918 | 0.80 | MAOB (0.66) | BRAFHDAC1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1026182 | 0.79 | BRAF (0.59) | BRAFHDAC1GCKHDAC3HDAC4 | |
| SCHEMBL18070541 | 0.78 | KDM4E (0.53) | HDAC1HDAC3HDAC2KEAP1CYP1A2 | |
| SCHEMBL13715199 | 0.78 | BRAF (0.58) | BRAFHDAC1GCKHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME CORP. | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065671-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | GPR119, GPR39, GPR65 | BRAF 4467/4885HDAC1 612/4885GCK 525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.