Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GCK | P35557 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | RNF4 | P78317 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13743721 | 0.89 | MAPK1 (0.42) | ALDH1A1HTTMITFPOLBMAPK1 | |
| SCHEMBL13715199 | 0.78 | BRAF (0.58) | GCKBRAFHDAC1PTGER4PTGER2 | |
| SCHEMBL13715272 | 0.74 | SMN1; SMN2 (0.44) | ALDH1A1HTTMAPK1GCKBRAF | |
| SCHEMBL13748324 | 0.66 | SERPINE1 (0.57) | ALDH1A1HTTBRAFHDAC1 | |
| SCHEMBL13743935 | 0.66 | BRAF (0.55) | MAPK1GCKBRAFHDAC1PTGER4 | |
| SCHEMBL13715264 | 0.65 | BRAF (0.54) | GCKBRAFHDAC1SMN1; SMN2SCN9A | |
| SCHEMBL24568246 | 0.65 | CES2 (0.52) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL5913136 | 0.65 | ALDH1A1 (0.51) | ALDH1A1HTTPOLBSMN1; SMN2 | |
| SCHEMBL29678316 | 0.65 | ALDH1A1 (0.51) | ALDH1A1HTTPOLBSMN1; SMN2 | |
| SCHEMBL1946930 | 0.65 | ALDH1A1 (0.71) | ALDH1A1HTTMITFPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572783-B2 | Obesity; N-(1-benzyl-piperidin-4-yl)-2-(2,5-dioxo-7-phenoxy-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl)-3-methyl-butyramide; modulators of ghrelin receptor (GHSR) | AMGEN INC. (US) | 2009-08-11 | — | — | US | disclosed |