Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22750876 | 0.90 | ROCK2 (0.51) | L3MBTL3ROCK2ROCK1GAAKDM4E | |
| SCHEMBL13716074 | 0.83 | ROCK2 (0.44) | ROCK2ROCK1KDM4EPOLBLMNA | |
| SCHEMBL13716161 | 0.82 | L3MBTL3 (0.62) | L3MBTL3GAAKDM4EPOLBRECQL | |
| SCHEMBL14393583 | 0.76 | RECQL (0.51) | L3MBTL3GAAKDM4EPOLBRECQL | |
| SCHEMBL8432259 | 0.76 | RECQL (0.54) | L3MBTL3GAAKDM4EPOLBRECQL | |
| SCHEMBL13716087 | 0.74 | ROCK2 (0.48) | ROCK2ROCK1KDM4ELMNAALDH1A1 | |
| SCHEMBL21078249 | 0.74 | ACHE (0.59) | L3MBTL3KDM4EL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13744553 | 0.74 | ACHE (0.72) | L3MBTL3GAAKDM4EPOLBRECQL | |
| SCHEMBL4703332 | 0.74 | KDM4E (0.57) | L3MBTL3GAAKDM4EPOLBRECQL | |
| SCHEMBL5909215 | 0.73 | L3MBTL3 (0.67) | L3MBTL3GAAKDM4EPOLBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572913-B2 | Inhibitors of Rho kinase; N-Benzyloxycarbonyl-4-[N''-(tert-butyloxycarbonyl)hydrazino]piperidine; 4-{[N''-(tert-butyloxycarbonyl)-N'-(1'-propyl)]hydrazino}piperidine | BIOAXONE THERAPEUTIQUE INC. (CA) | 2009-08-11 | — | — | US | disclosed |