Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9851511 | 0.81 | DRD3 (0.51) | ACHEDRD3ALDH1A1 | |
| SCHEMBL21078248 | 0.81 | L3MBTL3 (0.54) | DRD3L3MBTL3ALDH1A1L3MBTL1HPGD | |
| SCHEMBL8917126 | 0.80 | L3MBTL3 (0.84) | ACHEL3MBTL3BLMEPHX1L3MBTL1 | |
| SCHEMBL16757186 | 0.79 | KMT2A (0.65) | ACHEL3MBTL3ALDH1A1EPHX1L3MBTL1 | |
| SCHEMBL9851528 | 0.78 | HTR1A (0.57) | DRD3 | |
| SCHEMBL10763118 | 0.78 | ACHE (0.56) | ACHEL3MBTL3ALDH1A1BLMEPHX1 | |
| SCHEMBL10274485 | 0.78 | HDAC3 (0.67) | ACHEL3MBTL3ALDH1A1BLMEPHX1 | |
| SCHEMBL2618044 | 0.77 | ACHE (0.68) | ACHEL3MBTL3ALDH1A1BLMEPHX1 | |
| SCHEMBL18792902 | 0.77 | OPRM1 (0.65) | DRD3 | |
| SCHEMBL13478902 | 0.76 | L3MBTL3 (0.57) | ACHEL3MBTL3ALDH1A1BLMEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |