Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133227 | 1.00 | TP53 (0.41) | TP53METAP1ALOX5KDM4EGMNN | |
| SCHEMBL8152967 | 0.97 | — | — | |
| SCHEMBL7951463 | 0.86 | — | — | |
| SCHEMBL7277378 | 0.78 | REN (0.47) | TP53METAP1METAP2 | |
| Hydrochloric Acid SCHEMBL9848324 | 0.78 | REN (0.47) | TP53METAP1KDM4EGMNNLMNA | |
| SCHEMBL6548556 | 0.78 | TP53 (0.39) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL13169085 | 0.78 | TP53 (0.39) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL10305516 | 0.78 | DPP4 (0.43) | METAP1ALOX5 | |
| SCHEMBL453071 | 0.78 | SIGMAR1 (0.42) | METAP1ALOX5 | |
| SCHEMBL4756623 | 0.78 | TP53 (0.39) | TP53KDM4EGMNNLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756135-B1 | ESTER LINKED MACROLIDES USEFUL FOR THE TREATMENT OF MICROBIAL INFECTIONS | GLAXOSMITHKLINE ZAGREB (HR) | 2009-08-12 | — | — | EP | disclosed |