Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | AR | P10275 | 8/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23087947 | 0.84 | PRMT5 (0.42) | POLBLMNASMN1; SMN2ARPARP1 | |
| SCHEMBL23087487 | 0.77 | PRMT5 (0.62) | POLBLMNASMN1; SMN2ARPARP1 | |
| SCHEMBL11412658 | 0.76 | POLB (1.00) | POLBLMNASMN1; SMN2ARPARP1 | |
| SCHEMBL5163309 | 0.74 | POLB (0.72) | POLBLMNASMN1; SMN2ARPARP1 | |
| SCHEMBL13721614 | 0.74 | ALOX15 (0.42) | POLBLMNASMN1; SMN2ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL6279576 | 0.73 | POLB (0.70) | POLBLMNASMN1; SMN2ARPARP1 | |
| SCHEMBL5717747 | 0.73 | LMNA (1.00) | POLBLMNASMN1; SMN2ARPARP1 | |
| SCHEMBL30151141 | 0.73 | LMNA (1.00) | POLBLMNASMN1; SMN2ARPARP1 | |
| SCHEMBL10177081 | 0.71 | SMN1; SMN2 (0.64) | POLBLMNASMN1; SMN2ARPARP1 | |
| SCHEMBL30231202 | 0.71 | PRMT5 (0.68) | POLBLMNASMN1; SMN2ARPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859549-B2 | Potassium channel modulators | ABBVIE, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20120289500-A1 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289500-A1 | POTASSIUM CHANNEL MODULATORS | KCNQ1, KCNQ2, KCNJ2 | POLB 4320/4885LMNA 1022/4885SMN1; SMN2 1602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.